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LAB RESEARCH STUDIES

CLINICAL TRIALS

 

 

Genetics, Early Diagnosis, and New Treatments for Hemangiosarcoma

Status
Open

Study Goals
Hemangiosarcoma is an incurable disease that progresses slowly and usually goes undiagnosed until the late stages of disease. The goals of this study are to understand how heritable factors contribute to the disease, to develop simple, non-invasive tests that can be used to diagnose hemangiosarcoma before clinical signs are evident, and to develop new, effective and non-toxic treatments.

Eligibility criteria
Presently, samples are being accepted for the studies that seek to map genetic susceptibility factors for hemangiosarcoma, tumor genetics, and for on diagnostic development . We are especially seeking samples from Golden Retrievers, Portuguese Water Dogs and German Shepherd Dogs, but any dog with hemangiosarcoma may be eligible. This study is being conducted in collaboration with Drs. Matthew Breen of North Carolina State University, Elaine Ostrander of the National Human Genome Research Institute of the NIH, and Kerstin Lindblad-Toh of the Broad Institute of Harvard and MIT.

WHAT DO WE NEED?

  1. Susceptibility mapping - this requires germ line DNA (a blood sample) as well as pedigree information and a definitive diagnosis. Dogs are eligible regardless of treatment status or intent and samples can be collected before or during treatment (if during treatment, should be scheduled according to the timing of chemotherapy)
  2. Influence of breed/genetic background on tumor genomes and tumor phenotypes - this requires germ line DNA (a blood sample) AND a viable tumor biopsy. Click here to obtain instructions on how samples should be submitted. Samples must be collected before starting ANY treatment. Intent to treat is desirable, but not essential. For other eligibility criteria see below or contact us at lab@modianolab.org.
  3. Prognosis and prediction - the goal is to determine if breed or specific characteristics of the tumors influence response to therapy. This component requires germ line DNA (a blood sample) AND a viable tumor biopsy. Click here to obtain instructions on how samples should be submitted. Samples must be collected before starting ANY treatment. Intent to treat is desirable, but not essential. For other eligibility criteria see below or contact us at lab@modianolab.org.
  4. Diagnostic development - this requires a blood sample (3 - 5 ml of blood in EDTA) AND a viable tumor biopsy submitted by overnight courier between Tuesday and Friday. Click here to obtain instructions on how samples should be submitted. Samples must be collected before starting ANY treatment. Intent to treat is desirable, but not essential. Additional samples may be requested during the course of therapy. For other eligibility criteria see below or contact us at lab@modianolab.org.

If your Portuguese Water Dog has been diagnosed with hemangiosarcoma, please visit Dr. Ostrander's lab site or contact Dana Mosher (study coordinator) by email. Blood samples to map genetic susceptibility in this breed can be submitted directly to the NHGRI.

If your Golden Retriever has been diagnosed with hemangiosarcoma, please visit Dr. Lindblad-Toh's lab site or contact Sarah Fryc (study coordinator). Blood samples to map genetic susceptibility in this breed can be submitted directly to the Broad Institute.

If your dog has a tumor and you are willing to contribute tumor samples, please contact us at lab@modianolab.org, or contact Dr. Breen's lab for additional information.

If you wish to learn more about our efforts to develop new diagnostic tests and treatment options, pelase contact us at lab@modianolab.org. Please note that it may take up to 7-10 days for us to respond to these inquiries.

Financial incentive
There are no financial incentives to participate in these studies.

More Information
Please contact us at lab@modianolab.org

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