Skip Navigation

LAB RESEARCH STUDIES

CLINICAL TRIALS

 

 

Genetics of Osteosarcoma

Status
Open

Funding
The study is funded by the AKC Canine Health Foundation.

Study Goals
Many people know dogs that have died from osteosarcoma (bone cancer). Some breeds seem to be predisposed to this cancers. The AKC Canine Health Foundation is funding a study (led by Drs. Kerstin Lindblad-Toh and Kenine Comstock) to determine the genetic basis of these cancers. In time, the results from this and other studies may lead to genetic tests to define the risk or predisposition of dogs to develop osteosarcoma, and may identify those patients that are most likely to respond to conventional treatments. If your dog is newly diagnosed with osteosarcoma, you and your dog may be eligible to participate in this study and contribute to improve our understanding of what causes these cancers. Please check the eligibility criteria below.

WHAT DO WE NEED?
The study has several components that involve multiple collaborations.

  1. Susceptibility mapping - this requires germ line DNA (a blood sample) as well as pedigree information and a definitive diagnosis. Dogs are eligible regardless of treatment status or intent and samples can be collected before or during treatment (if during treatment, should be scheduled according to the timing of chemotherapy)
  2. Influence of breed/genetic background on tumor genomes and tumor phenotypes - this requires germ line DNA (a blood sample) AND a viable tumor biopsy. Click here to obtain instructions on how samples should be submitted. Samples must be collected before starting ANY treatment. Intent to treat is desirable, but not essential. For other eligibility criteria see below or contact us at lab@modianolab.org.
  3. Prognosis and prediction - the goal is to determine if breed or specific characteristics of the tumors influence response to therapy. This component requires germ line DNA (a blood sample) AND a viable tumor biopsy. Click here to obtain instructions on how samples should be submitted. Samples must be collected before starting ANY treatment. Intent to treat is desirable, but not essential. For other eligibility criteria see below or contact us at lab@modianolab.org.

Financial incentive
At this time, there is no financial incentive to participate in this project. In some cases, assistance may be available to cover costs to ship samples and for routine pathology tests, but in other cases, the family may need to be responsible for these costs.

Eligibility criteria
We are especially interested in samples from Rottweilers and Greyhounds, but any purebred dog with osteosarcoma may be eligible.

There are various ways to participate in these studies. Please contact us at lab@modianolab.org if you have questions or require additional details. Any samples can be submitted to our lab as long as we are provided at least 24 hr notice. Samples will be shared with other labs as appropriate, Please make sure to mark any box that allows samples to be shared in the appropriate Informed Consent Form.

Currently, the study is principally being conducted in collaboration with Drs. Kerstin Lindblad-Toh from the Broad Institute of Harvard and MIT and Kenine Comstock of the University of Michigan. For additional details and Informed Consent Forms, please visit http://www.dogdna.org

If you plan to seek treatment for your dog and are willing to contribute tumor samples, please contact us at lab@modianolab.org for additional information.

All PDF documents require the Adobe Acrobat Reader
Get Acrobat Reader