Selected Publications

Fosmire SP, Thomas R, Jubala CM, Wojcieszyn J, Valli VEO, Getzy DM, Smith TL, Gardner LA, Ritt MG, Bell JS, Freeman KP, Greenfield BE, Lana SE, Kisseberth WC, Helfand SC, Cutter GR, Breen M, Modiano JF. Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin T-cell lymphoma. Vet Pathol, 2007 Jul;44(4):467-78. PubMed, PDF

Lin P-Y, Fosmire SP, Park S-H, Park J-Y, Baksh S, Modiano JF, Weiss RH. (2007). ATTENUATION OF PTEN INCREASES p21 STABILITY AND CYTOSOLIC LOCALIZATION: POTENTIAL MECHANISM OF CHEMOTHERAPY RESISTANCE. Molecular Cancer, 6, 16 (doi:10.1186/1476-4598-6-16). PubMed, PDF

Modiano JF, Breen M, Valli VEO, Wojcieszyn JW, Cutter GR. PREDICTIVE VALUE OF p16 OR RB INACTIVATION IN A MODEL OF NATURALLY OCCURRING CANINE NON-HODGKIN LYMPHOMA. Leukemia. 2007 Jan;21(1):184-7. Epub 2006 Sep 21. PubMed, PDF

Khanna C, Lindblad-Toh K, Vail D, London C, Bergman P, Barber L, Breen M, Kitchell B, McNeil E, Modiano JF, Niemi S, Comstock KE, Ostrander E, Westmoreland S, Withrow S. THE DOG AS A CANCER MODEL. Nat Biotechnol. 2006 Sep; 24(9), 1065-1066. PubMed, PDF

Lamerato-Kozicki AR, Helm K, Jubala CM, Modiano JF. CANINE HEMANGIOSARCOMA ORIGINATES FROM HEMATOPOIETIC PRECURSORS WITH POTENTIAL FOR ENDOTHELIAL DIFFERENTIATION. Exp Hematol, 2006 Jul; 34 (7), 870-878. PubMed, PDF

Modiano JF, Breen M, Lana SE, Ehrhart N, Fosmire SP, Thomas R, Jubala CM, Lamerato-Kozicki AR, Ehrhart EJ, Schaack J, Duke RC, Cutter GR, Bellgrau D. NATURALLY OCCURRING TRANSLATIONAL MODELS FOR DEVELOPMENT OF CANCER GENE THERAPY. Gene Ther Mol Biol, 2006; 10, 31-40. Journal, PDF

Thomas R, Scott A, Langford C, Fosmire SP, Jubala CM, Lorentzen TD, Hitte C, Karlsson EK, Kirkness E, Ostrander EA, Galibert F, Lindblad-Toh K, Modiano JF, Breen M. CONSTRUCTION OF A 2MB RESOLUTION BAC-MICROARRAY FOR CGH ANALYSIS OF CANINE TUMORS. Genome Res. 2005 Dec; 15:1831-1837. PubMed, PDF

Dickerson EB, Thomas R, Fosmire SP, Lamerato-Kozicki AR, Scott A, Bianco SR, Wojcieszyn J, Breen M, Helfand SC, Modiano JF. MUTATIONS OF PHOSPHATASE AND TENSIN HOMOLOG DELETED FROM CHROMOSOME 10 IN CANINE HEMANGIOSARCOMA. Vet Pathol. 2005 Sept;42:618-632. PubMed, PDF

Modiano JF, Breen M, Burnett RC, Parker HG, Inusah S, Thomas R, Avery PR, Lindblad-Toh K, Ostrander EA, Cutter GR, Avery AC. DISTINCT B-CELL AND T-CELL LYMPHOPROLIFERATIVE DISEASE PREVALENCE AMONG DOG BREEDS INDICATES HERITABLE RISK. Cancer Res. 2005 Jul 1;65(13):5654-61. PubMed, PDF

Jubala CM, Wojcieszyn JW, Valli VE, Getzy DM, Fosmire SP, Coffey D, Bellgrau D, Modiano JF. CD20 EXPRESSION IN NORMAL CANINE B CELLS AND IN CANINE NON-HODGKIN LYMPHOMA. Vet Pathol. 2005 Jul;42(4):468-76. PubMed, PDF

Modiano JF, Lamerato-Kozicki AR, Jubala CM, Coffey D, Borakove M, Schaack S, Bellgrau D. FAS LIGAND GENE TRANSFER FOR CANCER THERAPY. Cancer Ther. 2004; 2(B) 561-70. Journal, PDF

Frazer-Abel AA, Baksh S, Fosmire SP, Willis D, Pierce AM, Meylemans H, Linthicum DS, Burakoff SJ, Coons T, Bellgrau D, Modiano JF. NICOTINE ACTIVATES NUCLEAR FACTOR OF ACTIVATED T CELLS C2 (NFATC2) AND PREVENTS CELL CYCLE ENTRY IN T CELLS. J Pharmacol Exp Ther. 2004 Nov;311(2):758-69. PubMed, PDF

Modiano JF, Sun J, Lang J, Vacano G, Patterson D, Chan D, Franzusoff A, Gianani R, Meech SJ, Duke R, Bellgrau D. FAS LIGAND-DEPENDENT SUPPRESSION OF AUTOIMMUNITY VIA RECRUITMENT AND SUBSEQUENT TERMINATION OF ACTIVATED T CELLS. Clin Immunol. 2004 Jul;112(1):54-65. PubMed, PDF

Fosmire SP, Dickerson EB, Scott AM, Bianco SR, Pettengill MJ, Meylemans H, Padilla M, Frazer-Abel AA, Akhtar N, Getzy DM, Wojcieszyn J, Breen M, Helfand SC, Modiano JF. CANINE MALIGNANT HEMANGIOSARCOMA AS A MODEL OF PRIMITIVE ANGIOGENIC ENDOTHELIUM. Lab Invest. 2004 May;84(5):562-72. PubMed, PDF

Bianco SR, Sun J, Fosmire SP, Hance K, Padilla ML, Ritt MG, Getzy DM, Duke RC, Withrow SJ, Lana S, Matthiesen DT, Dow SW, Bellgrau D, Cutter GR, Helfand SC, Modiano JF. ENHANCING ANTIMELANOMA IMMUNE RESPONSES THROUGH APOPTOSIS. Cancer Gene Ther. 2003 Sep;10(9):726-36. PubMed, PDF

Khare S, Banai Y, Gokulan K, Smith R 3rd, Linthicum DS, Modiano JF. EARLY CHANGES IN METABOLISM OF LEUKEMIC CELL LINES UPON INDUCTION OF APOPTOSIS BY CYTOTOXIC DRUGS. Eur J Pharmacol. 2003 Mar 28;465(1-2):23-30. PubMed, PDF

Baksh S, Widlund HR, Frazer-Abel AA, Du J, Fosmire S, Fisher DE, DeCaprio JA, Modiano JF, Burakoff SJ. NFATC2-MEDIATED REPRESSION OF CYCLIN-DEPENDENT KINASE 4 EXPRESSION. Mol Cell. 2002 Nov;10(5):1071-81. PubMed, PDF

Fernandes PJ, Modiano JF, Wojcieszyn J, Thomas JS, Benson PA, Smith R 3rd, Avery AC, Burnett RC, Boone LI, Johnson MC, Pierce KR. USE OF THE CELL-DYN 3500 TO PREDICT LEUKEMIC CELL LINEAGE IN PERIPHERAL BLOOD OF DOGS AND CATS. Vet Clin Pathol. 2002;31(4):167-82. PubMed, PDF

Koenig A, Bianco SR, Fosmire S, Wojcieszyn J, Modiano JF. EXPRESSION AND SIGNIFICANCE OF P53, RB, P21/WAF-1, P16/INK-4A, AND PTEN TUMOR SUPPRESSORS IN CANINE MELANOMA. Vet Pathol. 2002 Jul;39(4):458-72. PubMed, PDF

Dickerson EB, Fosmire S, Padilla ML, Modiano JF, Helfand SC. POTENTIAL TO TARGET DYSREGULATED INTERLEUKIN-2 RECEPTOR EXPRESSION IN CANINE LYMPHOID AND HEMATOPOIETIC MALIGNANCIES AS A MODEL FOR HUMAN CANCER. J Immunother. 2002 Jan-Feb;25(1):36-45. PubMed

Koenig A, Wojcieszyn J, Weeks BR, Modiano JF. EXPRESSION OF S100A, VIMENTIN, NSE, AND MELAN A/MART-1 IN SEVEN CANINE MELANOMA CELLS LINES AND TWENTY-NINE RETROSPECTIVE CASES OF CANINE MELANOMA. Vet Pathol. 2001 Jul;38(4):427-35. PubMed, PDF

Modiano JF, Mayor J, Ball C, Fuentes MK, Linthicum DS. CDK4 EXPRESSION AND ACTIVITY ARE REQUIRED FOR CYTOKINE RESPONSIVENESS IN T CELLS. J Immunol. 2000 Dec 15;165(12):6693-702. PubMed, PDF

Ritt MG, Mayor J, Wojcieszyn J, Smith R, Barton CL, Modiano JF. SUSTAINED NUCLEAR LOCALIZATION OF P21/WAF-1 UPON GROWTH ARREST INDUCED BY CONTACT INHIBITION. Cancer Lett. 2000 Sep 29;158(1):73-84. PubMed, PDF

Modiano JF, Mayor J, Ball C, Chitko-McKown CG, Sakata N, Domenico-Hahn J, Lucas JJ, Gelfand EW. QUANTITATIVE AND QUALITATIVE SIGNALS DETERMINE T-CELL CYCLE ENTRY AND PROGRESSION. Cell Immunol. 1999 Oct 10;197(1):19-29. PubMed, PDF

Modiano JF, Ritt MG, Wojcieszyn J, Smith R 3rd. GROWTH ARREST OF MELANOMA CELLS IS DIFFERENTIALLY REGULATED BY CONTACT INHIBITION AND SERUM DEPRIVATION. DNA Cell Biol. 1999 May;18(5):357-67. PubMed

Modiano JF, Ritt MG, Wojcieszyn J. THE MOLECULAR BASIS OF CANINE MELANOMA: PATHOGENESIS AND TRENDS IN DIAGNOSIS AND THERAPY. J Vet Intern Med. 1999 May-Jun;13(3):163-74. Review. PubMed

Boone LI, Knauer KW, Rapp SW, Stewart JF, Modiano JF. USE OF HUMAN RECOMBINANT ERYTHROPOIETIN AND PREDNISONE FOR TREATMENT OF MYELODYSPLASTIC SYNDROME WITH ERYTHROID PREDOMINANCE IN A DOG. J Am Vet Med Assoc. 1998 Oct 1;213(7):999-1001. PubMed

Chitko-McKown CG, Modiano JF. CLUES TO IMMUNE FUNCTION AND ONCOGENESIS PROVIDED BY EVENTS THAT ACTIVATE THE CELL CYCLE MACHINERY IN NORMAL HUMAN T CELLS. J Leukoc Biol. 1997 Oct;62(4):430-7. Review. PubMed

Helfand SC, Modiano JF, Moore PF, Soergel SA, MacWilliams PS, Dubielzig RD, Hank JA, Gelfand EW, Sondel PM. FUNCTIONAL INTERLEUKIN-2 RECEPTORS ARE EXPRESSED ON NATURAL KILLER-LIKE LEUKEMIC CELLS FROM A DOG WITH CUTANEOUS LYMPHOMA. Blood. 1995 Jul 15;86(2):636-45. PubMed

Modiano JF, Getzy DM, Akol KG, Van Winkle TJ, Cockerell GL. RETROVIRUS-LIKE ACTIVITY IN AN IMMUNOSUPPRESSED DOG: PATHOLOGICAL AND IMMUNOLOGICAL FINDINGS. J Comp Pathol. 1995 Feb;112(2):165-83. PubMed

Modiano JF, Kokai Y, Weiner DB, Pykett MJ, Nowell PC, Lyttle CR. PROGESTERONE AUGMENTS PROLIFERATION INDUCED BY EPIDERMAL GROWTH FACTOR IN A FELINE MAMMARY ADENOCARCINOMA CELL LINE. J Cell Biochem. 1991 Feb;45(2):196-206. PubMed

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